SportsLine's model simulated Cincinnati Reds vs. Pittsburgh Pirates 10,000 times and revealed its MLB picks for Wednesday's matchup at PNC Park

For the fourth time this season, and first time since April 3rd, the Reds fell 1-0 Tuesday night to the Pirates in Pittsburgh.

The Pirates (16-33) finally broke a scoreless tie in the bottom of the sixth inning when Bryan Reynolds ripped a single through the right side to plate Oneil Cruz from second. The run was all Falter (3-3) needed to earn his third victory of the season.

Preview the May 21 matchup between the Cincinnati Reds and Pittsburgh Pirates with recent trends, how to watch, livestream info, and more.

The Pirates have won in 11, or 33.3%, of the 33 contests they have been named as odds-on underdogs this year. Pittsburgh has a win-loss record of 9-19 when favored by +106 or worse by bookmakers this year.

The Pittsburgh Pirates will have one of their main starters back in the lineup against the Cincinnati Reds at PNC Park. Oneil Cruz will return to center field and to the leadoff spot in the second game vs.

MLB player prop bets and odds for Terry Lee Friedl on Tuesday, May 20, 2025, as the Cincinnati Reds take on the Pittsburgh Pirates.

The Cincinnati Reds beat the Pittsburgh Pirates 7-1 Monday in the first game of a 15-game stretch that includes 12 against division foes.