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mTORC2信号通路调控重组结核分枝杆菌CFP-10蛋白诱导巨噬细胞吞噬作用 ...
本研究针对结核分枝杆菌分泌蛋白CFP-10如何调控巨噬细胞免疫应答的机制展开探索,通过RNA-seq、流式细胞术及mTOR信号通路抑制剂干预实验,首次揭示CFP-10通过激活mTORC2信号通路增强巨噬细胞吞噬能力,同时抑制溶酶体酸化相关基因tmem199表达,为结核病免疫逃逸 ...
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