The Seattle Mariners (25-19) and the San Diego Padres (27-17) wrap up a 3-game interleague series Sunday at Petco Park in San Diego. First pitch is scheduled for 4:10 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the Mariners vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Get San Diego vs Seattle baseball betting preview, spread and over/under insights for their matchup on May 18.

The Seattle Mariners are more than halfway through their 10-game road trip. The Mariners are 5-1 through their first six game, comprised of a series sweep again

The Padres are favored at home (-170) against the Mariners (+143). The matchup on the mound for this contest is set with the San Diego Padres looking to Nick Pivetta (5-2), and Emerson Hancock (1-2) taking the ball for the Seattle Mariners.

MLB player prop bets and odds for Miguel Antonio Vargas on Wednesday, May 21, 2025, as the Chicago White Sox take on the Seattle Mariners.

Cal Raleigh led off the seventh inning with his 15th home run to break a tie, Dylan Moore had a two-run single in the ninth and the Seattle Mariners beat the San Diego Padres 4-1 on Saturday night.

Cease kept the score 1-0 until a questionable ball four call against Alejandro Kirk allowed him to start the bottom of the fifth inning with a leadoff walk. A struggling Anthony Santander was able to get to an inside pitch and hit a line drive home run to right field to put Toronto up, 3-0.