The New England Journal of Medicine is committed to responsible data sharing in the setting of clinical trials. To encourage an open discussion, the collection below explores diverse viewpoints ...

A total of 2516 participants underwent randomization; 1797 (71.4%) completed the trial. Of 2421 participants in the full analysis population (1209 assigned to the albuterol–budesonide group and ...

Squamous non–small-cell lung cancer (NSCLC) accounts for approximately 20 to 30% of all lung cancers and is associated with shorter survival than is nonsquamous NSCLC. 1-4 Historically, the lack ...

Peanut allergy, for which there are no approved treatment options, affects patients who are at risk for unpredictable and occasionally life-threatening allergic reactions. In a phase 3 trial, we ...

We and others identified retinoblastoma features that suggested that the tumors originate in long- and medium-wavelength cone precursors, and we discovered features of these cone precursors that ...

Recently, the complete genome sequence was determined for a multidrug-resistant strain of S. enterica serotype typhi (CT18), which was isolated in 1993 from a child with typhoid fever in the ...

Aspiration pneumonia is best considered not as a distinct entity but as part of a continuum that also includes community- and hospital-acquired pneumonias. It is estimated that aspiration ...

Autoimmune hemolytic anemia (AIHA) is defined as increased destruction of red cells through autoimmune mechanisms, usually mediated by autoantibodies against erythrocyte surface antigens. 1-3 ...

Alpha 1-antitrypsin (AAT) deficiency is one of the most common genetic diseases.Most persons carry two copies of the wild-type M allele of SERPINA1, which encodes AAT, and have normal circulating ...

Shown are the phases of rupture and healing of an atherosclerotic plaque. The cross-section of a plaque in Panel A shows a central core containing lipids and necrotic debris (yellow) and ...

Shown at the top is a normal alveolus. Panel A shows alveolar injury in organizing pneumonia. Epithelial cell injury with denudation of the epithelial basal laminae leads to gaps, followed by ...

Iron overload and hemochromatosis are common, treatable conditions. HFE genotypes, levels of serum ferritin, transferrin saturation values, and self-reported medical history were studied in a ...