Aldosterone synthase controls the synthesis of aldosterone and has been a pharmacologic target for the treatment of hypertension for several decades. Selective inhibition of aldosterone synthase ...

Decades of strict sentencing laws, the racially motivated “War on Drugs,” and simultaneous erosion of community mental health and social services have contributed to the American public health ...

Interactions between cardiac and kidney diseases have been classified as cardiorenal syndromes. A current classification 10 includes five types of cardiorenal syndromes: acute cardiac impairment ...

Snakes are predators, and with exceptions (e.g., egg-eating snakes), they subdue their prey through constriction, aggressive biting, and chewing or by using venom. The mechanism of venom delivery ...

Dr. Mallory C. Mandel (Pediatrics): A 16-year-old girl was admitted to this hospital because of abdominal pain. The patient had been in her usual state of health until 4 weeks before the current ...

Aspiration pneumonia is best considered not as a distinct entity but as part of a continuum that also includes community- and hospital-acquired pneumonias. It is estimated that aspiration ...

Higher serum urate levels are associated with an increased risk of diabetic kidney disease. Lowering of the serum urate level with allopurinol may slow the decrease in the glomerular filtration ...

Chronic spontaneous urticaria is an idiopathic syndrome defined by recurring itch, hives, or angioedema (or a combination of these symptoms) for more than 6 weeks. Remibrutinib, an oral, highly ...

Before the emergence of the B.1.617.2 (delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), vaccination reduced transmission of SARS-CoV-2 from vaccinated persons who ...

We and others identified retinoblastoma features that suggested that the tumors originate in long- and medium-wavelength cone precursors, and we discovered features of these cone precursors that ...

This review focuses on recent studies relevant to the management of hypertension in patients with COPD. Contemporary evidence concerning the effects of antihypertensive-drug classes on COPD ...

Although elevated levels of urea and creatinine define the progression and severity of AKI, their accumulation parallels that of less well-characterized metabolites that mediate the toxic effects ...